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Senescence

Senescence is a stress-induced state, where cells stop dividing. This state can result from common stresses, which include repeated cell division, genetic abnormalities, and toxicity of chemotherapy.  Accumulation of senescent cells is problematic because they secrete inflammatory factors, which exacerbate rheumatoid arthritis, osteoarthritis and other autoimmune conditions, neurodegenerative diseases (Alzheimer’s, Parkinson’s, ALS, and MS), and infectious disease. Senescent cells also interfere with the body’s innate defense and repair mechanisms.​ Targeting cellular senescence is now viewed as a means to impact age-related diseases. SIWA believes the role senescent cells play in disease can be exploited to treat specific aging and degenerative diseases and improve quality of life. As a result, therapies capable of clearing senescent cells represent a new approach for treating diseases either in combination with other treatments or as standalone therapies.

Diseases

Senescence has been found to be causally implicated in, or contributory to, multiple diseases as well as pediatric indications. These diseases include the following:
  • Arthritis (Osteo-and Rheumatoid)
  • Atherosclerosis
  • Cancer
  • Cancer Therapy–Related Disability
  • Hypertension
  • Ocular Diseases (such as Glaucoma)
  • Osteoporosis
  • Sarcopenia/Cachexia
  • Transplantation Rejection
  • Type 2 Diabetes
  • Yamamoto’s Muscular Dystrophy

Additionally, the National Organization for Rare Disease has classified several diseases that are caused or exacerbated by senescent cells, including:

  • Alzheimer’s Disease
  • Amyotrophic Lateral Sclerosis
  • Chronic Obstructive Pulmonary Disease
  • Huntington’s Chorea
  • Idiopathic Pulmonary Fibrosis
  • Juvenile Rheumatoid Arthritis (JRA)
  • Muscular Dystrophy (Becker’s, Duchenne, Limb-Girdle)
  • Ocular Diseases such as Macular Degeneration, Cataract Formation and Diabetic Retinopathy
  • Parkinson’s Disease
  • Progeria (Werner Syndrome and Hutchinson Gilford Progeria)